The Abstracts of Annual Report of Technical Progress

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Technical Report Abstracts

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N-(5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl)-L-glutamic acid (ICI D1694) is an analogue of the thymidylate synthase inhibitor, N'°-propargyl-5,8-dideazafolic acid (CB3717). CB3717 was found to be active in early clinical studies, but its use was limited by nephrotoxicity. ICI D1694 is a more potent antitumour agent than CB3717 and is also more water solubl...

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ژورنال

عنوان ژورنال: Journal of Science and Technology in Lighting

سال: 2019

ISSN: 2432-3225,2432-3233

DOI: 10.2150/jstl.ieij19a000001